Bulk Drug Manufacturing

Synbiotics to expand its bulk drug unit at Luna in Padra

Details: Category: Bulk Drug Manufacturing

Synbiotics to expand its bulk drug unit at Luna in Padra in Vadodara district of Gujarat. The production capacity after the proposed expansion will be 30.6 MTPA and it will be carried out at the existing premises. The total project cost is estimated at Rs. 50 million.

Details of products along with their production capacities are given below:

Sl .no	Product	Existing Quantity	Proposed Quantity	Total (MTPA)
01	Amphotericin-B	2.4	-	2.4
02	Acenocoumarol (Nicoumalone)	-	0.5	0.5
03	Fluphenazine Deconoate	-	0.2	0.2
04	Bupivacaine Hydrochloride	-	0.5	0.5
05	Crotamiton	-	10.0	10.0
06	Chromium Picolinate	-	5.0	5.0
07	Hydroxy Carbamide	-	1.0	1.0
08	Lignocaine Hydrochloride/ Lidocaine	-	6.0	6.0
09	Citirizine Hydrochloride	-	2.5	2.5
10	Fluconazole	-	2.5	2.5
	Total	2.4	28.2	30.6

Merck Lmited to expand its bulk drug unit at Marvasado in Ponda

Details: Category: Bulk Drug Manufacturing

Merck Lmited to expand its bulk drug unit at Marvasado in Ponda in Goa. The expansion will be within the existing land with an investment of Rs. 220 million.

The existing and proposed expansion of the products and their production capacity are as given below:

Sr. No	Name	Existing	Expansion	Total
1	Injectables	15/mio/month	-
2	Soft gel capsules	30 mio/month	-
3	Guaiazulene	12MT/year	-
4	Vitamin E Acetate bulk drug	25 MT/month	-
5	Vitamin E Acetate feed premixes	11.2 MT/month	-
6	Thiamine disulfide	22 MT/year	18 MT/ year	40 MT/ year
7	Oxynex ST	45 MT/year	105 MT/year	150 MT/year

Doctors Organic Chemicals to set up bulk drug unit at Illindakaparru

Details: Category: Bulk Drug Manufacturing

Doctors Organic Chemicals to set up bulk drug unit at Illindakaparru village in Irragavaram Mandal in West Godavari district of Andhra Pradesh. Land requirement of the project is around 11.48 acres. The total project cost is estimated at Rs. 120 million. The project involves expanding its bulk drug unit from 17.8 MTPM to 387.63 MTPM.

The details of the Products to be manufactured along with their production capacity are given below:

Existing Manufacturing Capacities

S.No	Existing Product	Quantity in Kg / Day
1.	Ibuprofen	1000
2.	Mefenamic Acid	200
3.	Chloramphenicol	60
4.	1-Cyano Cyclo Hexane Acetic Acid Ethyl Ester	293
Total		1553 (17.8MTPM)

Proposed Manufacturing Capacities

S. No.	Proposed Product	Capacity Kg/Day
1	Ibuprofen from Isobutyl Benzyl Propionaldehyde	200.00
2	Mefenamic Acid	300.00
3	1-Cyano Cyclo Hexane Acetic Acid Ethyl Ester	1700.00
4	Cyano Diester	2500.00
5	Metformin Hydrochloride	13600.00
6	a. Sertraline Hydrochloride b. Sertralone (Tetralone)	32.00 120.00
7	a. Tramadol Hydrochloride b. Meta Bromo Anisile	50.00 34.50
8	a. Carvedilol b. 4-Hydroxy Carbazole	7.00 5.00
9	Diphene Hydramine Hydrochloride	170.00
10	Clopidogrel Hydrogen Sulfate	24.00
11	Promethazine Hydrochloride	17.00
12	Glucosamine Hydrochloride	300.00
13	a. Glucosasmine Sulfate Sodium Chloride b. Glucosamine Sulfate Potassium Chloride	100.00 100.00
14	Paroxetine Hydrochloride Hemihydrate	10.00
15	a. Amitryptiline Hydrochloride b. Dibenzo Suberone	24.00 18.00
16	Chloramphenicol	50.00
17	Atenolol	50.00
	Total	19411.50 (387.63MTPM)

Jupiter Bioscience to expand its pharma unit at Cheriyal village

Details: Category: Bulk Drug Manufacturing

Jupiter Bioscience to expand its pharma unit at Cheriyal village in Sangareddy Mandal in Nalagonda district of Andhra Pradesh. The project involves setting up of

The details of various products Existing and Proposed and their production capacity are given below :

Sl. No	Name of product	Production Capacity (TPA*)	Proposed (TPA)
1	Trimethoprim	72.0	Existing - Dropped
2	2,6-Dimethoxy Phenol	15.0	Existing - Dropped
3	Sodium Azide	36.0	Existing - Dropped
4	2-Mehthyl Resorcinol	15.0	Existing - Dropped
Total Existing Production Capacity		138.0
	Proposed Regular Product
1.	Phloroglucinol Dihydrate	New	36.0
	* Proposed Campaign Products
2.	1,3,5-Trimethoxy Benzene	New	36.0
3.	Lisinopril	New	6.0
4.	1-Hydroxy Benzotriazole (HOBT)	New	12.0
5.	O-(Benzotriazole-1-yl)-N,N,N?N?-Tetra methyl Uronium Hexafluoro Phosphate (HBTU)	New	6.0
6.	o-(Benzotriazol-1-yl)-N,N,N?,N?-Tetramethyl Uronnium Tetra Fluoro Borate (TBTU) * Phloroglucinol Dihydrate and any three products will be manufactured at a time.	New	5.4
	* Proposed Campaign Products
7.	N-Hydroxy Succinimide (NHS)	New	12.0
8.	2-tertiary Butoxy Carbonyloxy lmino-2-Phenyl Acetonitrile (BOC-ON)	New	6.0
9.	9-Fluorenyl Methoxy Carbonyloxy Succinimide (FMOC-ONSU)	New	6.0
10.	Z-ONSU	New	12.0
11.	BOC ? Glycine	New	6.0
12.	Fmoc-L-Alanine	New	6.0
13.	Z-Glycine	New	6.0
14.	Leuprolide	New	6.0
15.	Oxytocin	New	2.4
16.	Ramipril	New	4.2
17.	Enalapril Maleate	New	7.8
Total Proposed Production capacity			96.0

The infrastructure is designed to manufacture all the above proposed change of products on regular and campaign basis i.e. Phloroglucinol Dihydrate on regular and any three drug products on campaign basis will be manufactured at a time. It is also noted that 1.0 TPH and 250 kg/hr(Standby) coal fired boilers and 2 nos. of 125 KVA DG Sets for standby power supply have been installed. Brine circulation in the condensers as well as receivers have been provided to recover solvent vapours. All reactors will be provided with dual condensers.