Bulk Drug Manufacturing

Prudence Pharma Chem to set up bulk drug unit at Ankleshwar

Details: Category: Bulk Drug Manufacturing

Prudence Pharma Chem to set up bulk drug unit at Ankleshwar in Bharuch district of Gujarat with an investment of Rs. 11.7 million. . It is proposed to stop the existing products and to manufacture various other bulk drugs and intermediates with installed capacity of 10 MTPM within the same premises. Besides 12 MTPM of Bulk Intermediates and by-products will be manufactured.

Details of products along with their production capacity are given below:

Sr. No.	Name of Products	Chemical Name of Product	Capacity, MT/Month
Group A
A-1.	Losarton Potassium (LSR)	(2-n-butyl-4-chloro-5-hydroxy-methyl-1-[(2`-(1H-tetrazol-5-yl potassium OR 2-n-Butyl-4-Chloro-l[{(2`-tetrazol-5- yl)-l,l`-bisphenyl-4-yl}methyl]-imidazole-5-methanol potassium OR [1- {2`- (2H-tetrazol-5-yl) biphenyl -4-yl}methyl]-2-butyl-4-chloro-1H-imidazol -5-yl) methanol potassium	3.0
A-2.	Metaxalone (MX)	5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one OR 5-(3,5-Dimethyl Phenoxy methyl)-2-oxazolidinone
A-3.	Amlodipine Besylate (AMB)	3-Ethyl 5-methyl (4RS)-2-[(2-aminoethoxy) methyl]-4-(2-chlorophenyl)-6-methyl-1, 4-dihydropyridine-3, 5-dicarboxylate benzenesulphonate.
Group B
B-1.	Glibenclamide (GLB)	1-[{4-(2-[(5-Chloro-2-ethoxybenzoyl) amino] ethyl) phenyl} sulphonyl]-3-cyclohexylurea.	7.0
B-2.	Niclosamide	5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide	7.0
Total Capacity (Group A + B)			10.0

List of Intermediate Products

Sr. No.	Production Stage	Chemical Name of Intermediate product	Kg/Kg of Finished product	Capacity, MT/Month
Group A
A-1	Stage 1 (LSR -1)	3-Butyl-4-chloro 5-methyl hydroxy N-(4-methyl 2-cyno biphenyl) imidazole	1.25	3.75
A-1	Stage 2 (LSR -2)	3-Butyl-4-chloro 5-methyl hydroxy N-(4-methyl 2-1 H tetrazole biphenyl) imidazole	1.00	3.00
A-2	Stage -1 (MX- 1)	2-[(3,5-dimethylphenoxy)methyl]oxirane	2.32	6.96
A-2	Stage -2 (MX- 2)	1-amino-2-(3,5-dimethylphenoxy)ethanol	1.67	5.01
A-3	Stage -1 (AMB- 1)	Hydroxy ethyl Phthlamide [HEP ]	1.35	4.05
	Stage -2 (AMB- 2)	Methy 3 Amino Crotonate [MAC]	2.00	6.00
	Stage -3 (AMB- 3)	Ethyl -4-(2-Phthlamide) ethyl aceto acetate. [PHEMA] & Phthloyal Amlodipine	1.50	4.50
	Stage -4 (AMB- 4)	Amlodipine Base	1.00	3.00
B-4	Stage -2 (GLB 2)	Sulphonamide	0.72	5.04
	Maximum Capacity	Group A		6.96
	Maximum Capacity	Group B		5.04
		Total Capacity (Group A + B)		12.00

* The unit may sale intermediate products at any stage as stated above from the manufacturing of each product.

* The maximum production capacity of intermediate products will not exceed 12.00 MT/Month

List of By-Products

Sr. No.	Source	Name Of The Byproducts	Capacity, MT/Month
GROUP A
1.	APCE for Metaxalone (A -2 )	Liquid Ammonia	150.00
GROUP - B
1.	APCE for Glibenclamide (A -2 )	HCl Solution	6.70
1.	APCE for Glibenclamide (A -2 )	Sodium bi Sulphite	9.80
2.	APCE for Niclosamide (A -2 )	HCl Solution	3.00
2.	APCE for Niclosamide (A -2 )	Sodium bi Sulphite	4.40

	Maximum Capacity	Liquid Ammonia	150.00
		HCl Solution	6.70
Sodium bi Sulphite		9.80

Alembic to expand its drug unit at Vadodara

Details: Category: Bulk Drug Manufacturing

Alembic to expand its drug unit at Vadodara in Gujarat with an investment of Rs. 2690 million. The project involves expanding Penicillin G- manufacturing unit from 83.33 MMU to 240 MMU

Details of products and with their production capacities are given below:

SR. NO.	NAME OF PRODUCT	CAPACITY (PER MONTH)
SR. NO.	NAME OF PRODUCT	EXISTING	TOTAL AFTER PROPOSED EXPANSION
	Penicillin G	83.33 MMU	240 MMU
	Erythromycin (Thio)	10.5 T	10.5 T
	Erythromycin Estolate	7.4 T	7.4 T
	Protinules Powder	20 T	-
	Tablets and capsules	150 lacs Tablet & 5 lacs Capsules	-
	Injectables (dry powder)	10 T	-
	Liquid oral preparations	16 lacs unit	-
	Roxithromycin	5 T	5 T
	Cephalosporin - C	10 T	10 T
	Sod. Penicillin G	12 MMU	12 MMU
	Benzathine Penicillin G	2.5 T	2.5 T
	Procaine Penicillin G	14.5 MMU	14.5 MMU
	Sterile Azithromycin	200 kg	-
	Dried Yeast Powder	9.85 T	9.85 T
	Rofecoxib	360 Kg	360 Kg
	Pioglitazon HCL	15 Kg	15 Kg
	Mosapride Citrate	15 Kg	15 Kg
	Meloxicam	48 Kg	48 Kg
Note : 1 MMU Penicillin = 1000 BU = Approx. 640 Kg.

Production of product no. 4 to 7 & 13 already stopped since 2003

Surya Drugs & Pharmaceuticals to expand it bulk drug unit at Ankleshwar

Details: Category: Bulk Drug Manufacturing

Surya Drugs & Pharmaceuticals to expand it bulk drug unit at Ankleshwar in Bharuch district of Gujarat with an investment of Rs. 5.0 million. The project involves expanding bulk drugs & fine chemicals manufacturing unit from 5 MTPM to 50 MTPM.

. Details of products and their production capacities are given below:

Sr. No.	Product	Capacity (MTPM)
Existing
1	2:4:5 Tri Chloro Nitro Benzene	2
2	Spent Sulphuric Acid	3
Proposed
1	Gabapentine HCl	30
2	Glimipiride HCl	25
3	Lamotrigine	30
4	Lidocaine HCl	15
5	Phenyl Propyl Amine HCl	25
6	Quinine Sulphate	3
7	Terbutaline Sulphate	20
8	Venlafexine HCl	15
9	Para Anisyl Alcohol	50
10	Salbutamol Sulphate	5
11	Meta Phenoxy Benzyl Alcohol	30
12	Phenanthrene	20
13	Oxcarbazepine	20
14	Meta Bromo Anisol	20
15	Sucralfate	30

* The unit proposes to manufacture 50 MT/month any of the above product individually or combination from any above product.

JNP Products to expand its bulk drug unit at Jhagadia in Bharuch

Details: Category: Bulk Drug Manufacturing

JNP Products to expand its bulk drug unit at Jhagadia in Bharuch district of Gujarat with an investment of Rs. 150 million. Presently the unit is manufacturing 4 Amino Phenol (PAP Slurry) at a production capacity of 500 MTPM which is used for manufacturing paracetamol. After expansion, production capacity will increase to 1650 MTPM. The land available with the company is 26000 m². Expansion will be carried within the existing unit.